Driving distance from Greenville, SC to Saint Charles, MO is 676 miles (1088 km). How far is it from Greenville, SC to Saint Charles, MO? It's a 11 hours 22 minutes drive by car. Flight distance is approximately 525 miles (845 km) and flight time from Greenville, SC to Saint Charles, MO is 01 hours 03 minutes. Don't forget to check out our "Gas cost calculator" option. It will calculate cost of driving this particular distance. See the map below for the visual display of the upcoming road trip.
To travel the distance from Greenville, SC to Saint Charles, MO, please, click on the map to see the route for the journey. "Gas Cost Calculator" tool is to your right. You can always modify it and make the number more applicable for your journey.
Choose a place to stay while traveling from Greenville, SC to Saint Charles, MO. We also offer Car Rental widget for your particular journey. There are lots of options to choose from. Give it a try.
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