Driving distance from Louisville, KY to Cape Girardeau, MO is 258 miles (416 km). How far is it from Louisville, KY to Cape Girardeau, MO? It's a 04 hours 23 minutes drive by car. Flight distance is approximately 215 miles (347 km) and flight time from Louisville, KY to Cape Girardeau, MO is 26 minutes. Don't forget to check out our "Gas cost calculator" option. It will calculate cost of driving this particular distance. See the map below for the visual display of the upcoming road trip.
To travel the distance from Louisville, KY to Cape Girardeau, MO, please, click on the map to see the route for the journey. "Gas Cost Calculator" tool is to your right. You can always modify it and make the number more applicable for your journey.
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